Patrick Cadet

Patrick Cadet's picture
Associate Professor
Director of NRI
Co-director of CSTEP & LSAMP
Natural Sciences
  • Post-doctoral Research in Microbiology, Vanderbilt University Medical Center (Nashville, TN)
  • Ph.D. in Virology/Immunology University of Texas Medical Branch (Galveston, TX)
  • M.A. in Biology Hofstra University (East Garden City, NY)
  • B.S. in Biology SUNY College at Old Westbury (Old Westbury, NY)
  1. Stefano, GB, Cadet, P, Scharrer, B. Stimulatory effects of opioid neuropeptides on locomotory activity and conformational changes in invertebrate and human immunocytes: Evidence for a subtype of delta receptor. Proc. Natl. Acad. Sci. USA. 86(16) p 6307-6311, 1989.
  2. Hughes, TK, Cadet, P, Larned, CS. Modulation of tumor necrosis factor activities by a potential anti-cachexia compound, hydrazine sulfate. Int. J. Immunopharmacol. 11(5). p 501-507, 1989.
  3. Hughes, TK, Smith, EM, Chin, R, Cadet, P, Sinistera, J, Leung, MK, Shipp, MA, Scharrer, B, Stefano, GB. Interaction of immunoactive monokines (interleukin-1 and tumor necrosis factor) in the bivalve mollusc Mytilus edulis. Proc. Natl. Acad. Sci. USA. 87(12). p 4426-4429, 1990.
  4. Stefano, GB, Cadet, P, Dokun, A, Scharrer, B. A Neuroimmunoregulatory-like mechanisms responding to stress in the marine bivalve Mytilus edulis. Brain, Behavior, and Immunity. 4(4). p 323-329, 1990.
  5. Stefano, GB, Cadet, P, Sinistera, J, Leung, MK, Scharrer, B. Neural Activation of the Cellular Immune System Involving an Opioid mechanism in the Mollusc Mytilus edulis. Ann. NY. Acad. Sci. Vol. 594, 1990.
  6. Smith, EM, Hughes, TK, Cadet, P, Stefano, GB. Corticotropin releasing factor induced immunosuppression in human and in invertebrate immunocytes. Cell. Mol. Neurobiol. 12(5). p 473-481, 1992.
  7. Stefano, GB, Smith, EM, Cadet, P. Hughes, TK. HIV gp-120 alteration of DAMA and IL-1 alpha induced chemiotaxic responses in human and invertebrate immunocytes. Journal of Neuroimmunology. 43, 177-184, 1993.
  8. Cooper, E, Leung, MK, Suzuki, MM, Vick, K, Cadet, P, Stefano, GB. An enkephalin-like molecule in earthworm coelomic fluid modifies leukocyte behavior. Dev. Comp. Immunol. 17(3). p 201-209, 1993.
  9. Ottaviani, E, Paemen, LR, Cadet, P, Stefano, GB. Evidence for nitric oxide production and utilization as a bacteriocidal agent by invertebrate immunocytes. Eur. J. Pharmacol. 248, 319-324, 1993.
  10. Hughes, TK, Cadet, P, Rady, PL, Tyring, SK, Chin, R, Smith, EM. Evidence for production and action of interleukin-10 in the pituitary cells. Cell. Molec. Neurobiol. 14(1). p 59-69, 1994.
  11. Cadet, P, Rady, PL, Tyring, SK, Yandel, RB, Hughes, TK. Interleukin-10 mRNA in human placenta: Implications of a role for IL-10 in fetal allograft protection. Am. J. Obstet. Gynecol. 173(1) 25-29, 1995.
  12. Rady, PL, Smith, EM, Cadet, P, Opp, MR, Tyring, SK, Hughes, TK. Presence of interleukin-10 transcripts in human pituitary and hypothalamus. Cell. Molec. Neurobiol. 15(2). p 289-295, 1995.
  13. Rady, PL, Cadet, P, Bui, TK, Tyring, SK, Baron, S, Stanton, GJ, Hughes, TK. Production of IFN-gamma messenger RNA by cells of non-immune origin. Cytokine. 7(8). p 793-798, 1995.
  14. Opp, MR, Rady, PL, Hughes, TK, Cadet, P, Smith, EM. Human immunodeficiency virus envelope glycoprotein 120 alters sleep and induces cytokine mRNA expression in rats. Am J Physiol. 270( pt 2):R963-70, 1996.
  15. Stefano, GB, Prevot, V, Beauvillain, JC, Fimiani, C, Welters, I, Cadet, P, Breton, C, Pestel, J, Salzet, M , Bilfinger, TV. Estradiol coupling to human monocyte nitric oxide release is dependent on intracellular calcium transients: Evidence for an estrogen surface receptor. J Immunol. 163(7):3758-3763, 1999.
  16. Cadet, P, Stefano, GB. Mytilus edulis pedal ganglia express mu opiate receptor transcript exhibiting high sequence identity with human neuronal mu-1. Brain Res Mol Brain Res. 74(1-2):242-6, 1999.
  17. Smith, EM, Cadet, P, Stefano, GB, Opp, MR, Hughes, TK Jr. IL-10 as a mediator in the HPA axis and brain. J Neuroimmunol. 100(1-2): 140-8, 1999.
  18. Stefano, GB, Goumon, Y, Bilfinger, TV, Welters, I, Salzet, B, Cadet, P. Basal nitric oxide limits immune, nervous and cardiovascular excitation: Human endothelia express a mu opiate receptor. Prog Neurobiol. 60(6): 513-30, 2000.
  19. Stefano, GB, Prevot, V, Beauvillain JC, Cadet, P, Fimiani, C, Welters, I, Fricchione, GL, Breton, C, Lassalle, P, Salzet, M, Bilfinger, TV. Cell-surface estrogen receptors mediate calcium-dependent nitric oxide release in human endothelia. Circulation. 101(13): 1594-7, 2000.
  20. Cadet, P, Bilfinger, TV, Fimiani, C, Peter, D, Stefano, GB. Human Vascular endothelia express mu opiate receptor transcripts. Endothelium. 7(3): 185-91, 2000.
  21. Goumon, Y, Casares, F, Pryor, S, Ferguson, L, Brownawell, B, Cadet, P, Rialas, CM, Welters, ID, Sonetti, D, Stefano, GB. Ascaris suum, an intestinal parasite, produces morphine. J. Immunol. 165(1): 339-43, 2000.
  22. Stefano, GB, Cadet, P, Breton, C, Goumon, Y, Prevot, V, Dessaint, JP, Beauvillain, JC, Roumier, AS, Welters, I Salzet, M. Estradiol-stimulated nitric oxide release in human granulocytes is dependent on intracellular calcium transients: evidence of a cell surface estrogen receptor. Blood. 95(12):3951-8, 2000.
  23. Stefano, GB, Goumon, Y, Casares, F, Cadet, P, Fricchione, GL, Rialas, C, Peter, D, Sonetti, D, Guarna, M, Welters, ID, Bianchi, E. Endogenous morphine. Trends Neurosci. 23(9):436-42, 2000.
  24. Goumon, Y, Zhu, W, Weeks, BS, Casares, F, Cadet, P, Bougaeva, M, Brownawell, B, Stefano, GB. Identification of morphine in the adrenal medullary chromaffin PC-12 cell line. Mol Brain Res. 81:177-180, 2000.
  25. Welters ID, Menzebach A, Goumon Y, Cadet P, Menges T, Hughes TK, Hempelmann G, Stefano GB. Morphine inhibits NF-kappaB nuclear binding in human neutrophils and monocytes by a nitric oxide dependent mechanism. Anesthesiology. 2000 Jun;92(6):1677-84.
  26. Stefano GB, Prevot V, Cadet P, Dardik I. Vascular pulsations stimulating nitric oxide release during cyclic exercise may benefit health: a molecular approach (review). Int J Mol Med. 2001 Feb;7(2):119-29. Review.
  27. Rialas CM, Weeks B, Cadet P, Goumon Y, Stefano GB. Nociceptin, endomorphin-1 and -2 do not interact with invertebrate immune and neural mu 3 opiate receptor. Acta Pharmacol Sin. 2000 Jun;21(6):516-20.
  28. Cadet P, Weeks BS, Bilfinger TV, Mantione KJ, Casares F, Stefano GB. HIV gp120 and morphine alter &mgr; opiate receptor expression in human vascular endothelium. Int J Mol Med. 2001 Aug;8(2):165-9.
  29. Weeks BS, Alston NI, Cadet P, Zhu W, Rialas C, Stefano GB. Morphine reduces herpes simplex virus-1 pathogenesis in the murine flank. Int J Mol Med. 2001 Sep;8(3):303-7.
  30. Weeks BS, Goldman S, Touma S, Payne M, Cadet P, Stefano GB. Morphine inhibits indolactam V-induced U937 cell adhesion and gelatinase secretion. J Cell Physiol. 2001 Nov;189(2):179-88.
  31. Cadet P, Mantione K, Bilfinger TV, Stefano GB. Real-time RT-PCR measurement of the modulation of Mu opiate receptor expression by nitric oxide in human mononuclear cells. Med Sci Monit. 2001 Nov-Dec;7(6):1123-8.
  32. Stefano GB, Neenan K, Cadet P, Magazine HI, Bilfinger TV. Ischemic preconditioning - an opiate constitutive nitric oxide molecular hypothesis. Med Sci Monit. 2001 Nov-Dec;7(6):1357-75.
  33. Stefano GB, Cadet P. Computer-assisted microscopic image analysis in immunology. Chemotaxis and Migration. 2(52):59, 2001.
  34. Weeks BS, Goldman S, Touma S, Payne M, Cadet P, Stefano GB. Indolactam V induces U937 cell adhesion to extracellular matrix proteins and gelatinase secretion: Morphine inhibits indolactam V effects in a nonspecific manner. J Cell Physiol.. 189((2): 179-188, 2001.
  35. Benz D, Cadet P, Mantione K, Zhu W, Stefano GB. Tonal nitric oxide and health: A free radical and a scavenger of free radicals. Med Sci Monit. 8(1):RA1-RA4, 2002.
  36. Benz D, Cadet P, Mantione K, Zhu W, Stefano GB. Tonal nitric oxide and health: Anti-bacterial and –viral actions and implications for HIV. Med Sci Monit. 8(2):RA27-31, 2002.
  37. Stefano GB, Fulop ZI, Rialas CM, Cadet P, Zhu W, Rotondo M. Nitric oxide is involved in the relaxation response. Brain Res Cogn Brain Res. In press.
  38. Stefano GB, Zhu W, Cadet P, Mantione K, Bilfinger TV, Bianchi E, Guarna M. An hormonal role for endogenous opiate alkaloids: Vascular tissues. Neuroendocrinal Lett. 23(1):21-6, 2002. 
  39. Mantione K, Zhu W, Rialas C, Casares F, Cadet P, Franklyn AL, Tonnesen J, Stefano GB. Morphine 6 Glucoronide Stimulates Nitric Oxide Release in Mussel Neural Tissue: Evidence for a Morphine 6 Glucoronide Opiate Receptor Subtype. Cell Mol Life Sci. 59(3):21-6, 2002
  40. Stefano GB, Cadet P, Zhu W, Rialas CM, Mantione K, Benz D, Fuentes R, Casares F, Fricchione GL, Fulop Z, Slingsby B. The blueprint for stress can be found in invertebrates. Neuroendocrinal Lett. 23(2):85-93, 2002.
  41. Cadet P, Mantione K, Bilfinger TV, Stefano GB. Morphine down regulates human vascular tissue estrogen receptor expression determined by real-time RT-PCR. Neuroendocrinal Lett. 23(2):95-100, 2002.
  42. Rasmussen M, Zhu W, Tonnensen J, Cadet P, Tonnesen E, Stefano GB. Effects of morphine on tumor growth. Neuroendocrinal Lett. 23(3):193-8, 2002.
  43. Cho JJ, Cadet P, Salamon E, Mantione K, Stefano GB. The nongenomic protective effects of estrogen on the male cardiovascular system: clinical and therapeutic implications in aging men. Med Sci Monit. 2003 Mar;9(3):RA63-8.
  44. Stefano GB, Cadet P, Mantione K, Cho JJ, Jones D, Zhu W. Estrogen Signaling at the Cell Surface Coupled to Nitric Oxide Release in Mytilus edulis Nervous System. Endocrinology. 2003 Apr;144(4):1234-40.
  45. Stefano GB, Cadet P, Rialas CM, Mantione K, Casares F, Goumon Y, Zhu W. Invertebrate opiate immune and neural signaling. Adv Exp Med Biol. 2003;521:126-47.
  46. Cadet P, Mantione KJ, Stefano, GB. Molecular identification and functional expression of mu3, a novel alternatively spliced variant of the human mu opiate receptor gene. Journal of Immunol. 2003; May 15;170(10): 5118-23.
  47. Mantione K, Hong R, Im R, Nam JH, Simon M Cadet P, Stefano, GB. Effects of cold stress on morphine-induced nitric oxide production and mu-opiate receptor gene expression in Mytilus edulis pedal ganglia. Neuroendocrinal Lett. 2003 Feb-Apr; 24(1-2):68-72.
  48. Stefano GB, Esch T, Cadet P, Zhu W, Mantione K, Benson H. Endocannabinoids as autoregulatory signaling molecules: coupling to nitric oxide and a possible association with the relaxation response. Med Sci Monit. 2003 Apr; 9(4): RA63-75.
  49. Cadet P, Zhu W, Mantione K, Rymer M, Dardik I, Reisman S, Hagberg S, Stefano GB. Cyclic exercise induces anti-inflammatory signal molecule increases in the plasma of Parkinson’s patients. Int J Mol Med. 2003 Oct; 12(4): 485-92.
  50. Zhu W, Ma Y, Cadet P, Yu D, Bilfinger TV, Bianchi E, Stefano GB. Presence of reticuline in rat brain: a pathway for morphine synthesis. Brain Res Mol Brain Res. 2003 Sep 10; 117(1): 83-90.
  51. Stefano GB, Zhu W, Mantione K, Jones D, Salamon E, Cho JJ, Cadet P. 17-beta estradiol down regulates ganglionic microglial cells via nitric oxide release: presence of an estrogen receptor beta transcript. Neuroendocrinal Lett. 2003 Jun-Aug; 24(3-4): 130-6.
  52. Zhu w, Mantione K, Jones D, Salamon E, Cho JJ, Cadet P, Stefano GB. The presence of 17-beta estradiol in Mytilus edulis gonadal tissues: evidence for estradiol isoforms. Neuroendocrinal Lett. 2003 Jun-Aug; 24(3-4): 137-40.
  53. Stefano GB, Kim E, Liu Y, Zhu W, Casares F, Mantione K, Jones DA, Cadet P. Nitric oxide modulates microglial activation. Med Sci Monit. 2004 Feb; 10(2): BR17-22.
  54. Cadet P. Morphine Modulates the Physiological Control of Ciliary Activity in the Marine Mussel Mytilus edulis via Nitric Oxide. Accepted for publication, Neuroendocrin lett, 25(3): June 2004. 
  55. Cadet P. Mu Opiate Receptor Subtypes. Med Sci Monit. June 1, 2004.
  56. Stefano GB, Zhu W, Cadet P, Salamon E, Mantione KJ. Music alters constitutively expressed opiate and cytokine processes in listeners.Med Sci Monit. 2004 Jun 1.
  57. Stefano GB, Mantione K, Jones D, Zhu W, Casares F, Cadet P. Immunocytes modulate ganglionic nitric oxide release which later affects their activity level. Neuroendocrinal Lett. 2004 Feb-Apr;25(1-2):57-61.
  58. Stefano GB, Zhu W, Cadet P, Bilfinger TV, Mantione K. Morphine enhances nitric oxide release in the mammalian gastrointestinal tract via the micro(3) opiate receptor subtype: a hormonal role for endogenous morphine. J Physiol Pharmacol. 2004 Mar;55(1 Pt 2):279-88.
  59. Zhu W, Pryor SC, Putnam J, Cadet P, Stefano GB. Opiate alkaloids and nitric oxide production in the nematode Ascaris suum.J Parasitol. 2004 Feb;90(1):15-22.
  60. Cadet P, Rasmussen M, Zhu W, Tonnesen E, Mantione KJ, Stefano GB. Endogenous morphinergic signaling and tumor growth. Front Biosci. 2004 Sep 1;9:3176-86.
  61. Cadet P, Mantione KJ, Bilfinger TV, Stefano GB. Differential expression of the human mu opiate receptor from different primary vascular endothelial cells. Med Sci Monit. 2004 Oct;10(10):BR351-5. Epub 2004 Sep 23.
  62. Stefano GB, Burrill JD, Labur S, Blake J, Cadet P.Regulation of various genes in human leukocytes acutely exposed to morphine: expression microarray analysis. Med Sci Monit. 2005 May;11(5):MS35-42. Epub 2005 Apr 28.
  63. Cadet P. Morphine and neuro-endocrine function. Med Sci Monit. 2005 Sep;11(9):LE8-9. Epub 2005 Aug 26.
  64. Pryor SC, Zhu W, Cadet P, Bianchi E, Guarna M, Stefano GB. Endogenous morphine: opening new doors for the treatment of pain and addiction. Expert Opin Biol Ther. 2005 Jul;5(7):893-906.
  65. Pak T, Cadet p, Mantione KJ, Stefano GB. Morphine via nitric oxide modulates beta-amyloid metabolism: a novel protective mechanism for Alzheimer's disease. Med Sci Monit. 2005 Oct;11(10):BR357-366. Epub 2005 Sep 26.
  66. Zhu W, Cadet P, Baggerman G, Mantione KJ, Stefano GB. Human white blood cells synthesize morphine: CYP2D6 modulation. J Immunol. 2005 175(11):7357-62. 
  67. Zhu W, Mantione KJ, Shen L, Cadet P, Esch T, Goumon Y, Bianchi E, Sonetti D, Stefano GB. Tyrosine and tyramine increase endogenous ganglionic morphine and dopamine levels in vitro and in vivo: cyp2d6 and tyrosine hydroxylase modulation demonstrates a dopamine coupling. Med Sci Monit. 2005 11(11):BR397-404.
  68. Rambhia S, Mantione KJ, Stefano GB, Cadet P. Morphine modulation of the ubiquitin-proteasome complex is neuroprotective. Med Sci Monit. 2005 11(11):BR386-96. 
  69. Zhu W, Mantione KJ, Casares FM, Cadet P, Kim JW, Bilfinger TV, Kream RM, Khalill S, Singh S, Stefano GB. Alcohol-, nicotine-, and cocaine-evoked release of morphine from invertebrate ganglia: model system for screening drugs of abuse. Med Sci Monit. 2006 12(5):BR155-61. 
  70. Stefano GB, Bianchi E, Guarna M, Fricchione GL, Zhu W, Cadet P, Mantione KJ, Casares FM, Kream RM, Esch T.Nicotine, alcohol and cocaine coupling to reward processes via endogenous morphine signaling: the dopamine-morphine hypothesis. Med Sci Monit. 2007 Jun;13(6):RA91-102. Review.
  71. Mantione KJ, Cadet P, Zhu W, Kream RM, Sheehan M, Fricchione GL, Goumon Y, Esch T, Stefano GB.Endogenous morphine signaling via nitric oxide regulates the expression of CYP2D6 and COMT: autocrine/paracrine feedback inhibition. Addict Biol. Addict Biol. 2008 Feb 4;13(1):118-123. Epub 2007 Jun 16.
  72. Welters ID, Menzebach A, Goumon Y, Langefeld TW, Harbach H, Muhling J, Cadet P, Stefano GB.Morphine inhibits AP-1 activity and CD14 expression in leukocytes by a nitric oxide and opioid receptor-dependent mechanism. Eur J Anaesthesial. 2007 Nov;24(11):958-965. Epub 2007 Jun 22.
  73. Zhu W, Mantione KJ, Kream RM, Cadet P, Stefano GB.Cholinergic regulation of morphine release from human white blood cells: evidence for a novel nicotinic receptor via pharmacological and microarray analysis. Int J Immunopathol Pharmacol. 2007 Apr-Jun;20(2):229-37.
  74. Stefano GB, Kream RM, Mantione KJ, Sheehan M, Cadet P, Zhu W, Bilfinger TV, Esch T. Endogenous morphine/nitric oxide-coupled regulation of cellular physiology and gene expression: Implications for cancer biology. Semin Cancer Biol. 2008 Jun;18(3):199-210.
  75. Kream RM, Sheehan M, Cadet P, Mantione KJ, Zhu W, Casares F, Stefano GB. Persistence of evolutionary memory: primordial six-transmembrane helical domain mu opiate receptors selectively linked to endogenous morphine signaling. Med Sci Monit. 2007 Dec;13(12).
  76. Cadet P, Mantione KJ, Zhu W, Kream RM, Sheehan M, Stefano GB. A functionally coupled mu3-like opiate receptor/nitric oxide regulatory pathway in human multi-lineage progenitor cells. J Immunol. 2007 Nov 1;179(9):5839-44.
  77. Fricchione G, Zhu W, Cadet P, Mantione KJ, Bromfield E, Madsen J, DeGirolami U, Dworetzky B, Vaccaro B, Black P, Stefano GB. Identification of endogenous morphine and a mu3-like opiate alkaloid receptor in human brain tissue taken from a patient with intractable complex partial epilepsy. Med Sci Monit. 2008 Jun;14(6):CS45-49
  78. Stefano GB, Cadet P, Kream RM, Zhu W. The presence of endogenous morphine signaling in animals. Neurochem Res. 2008 Oct;33(10):1933-9
  79. Cadet p. Monitoring Emerging Infectious Disease. IMEID, 2008; 1(1): ED1
  80. Zhu W, Cadet P. Mytilus edulis opiate processes. Arch Med Sci. Dec 2009. Submitted.
  81. Mantione KJ, Angert RM, Cadet P, Kream RM, Stefano GB. Identification of a µ opiate receptor signaling mechanism in human placenta. Med Sci Monit. 2010 Nov;16(11):BR347-52
  82. Kim C, Cadet P. (2010) Environmental toxin 4-nonylphenol and autoimmune diseases: using DNA microarray to examine genetic markers of cytokine expression. Arch Med Sci. Jun 30; 6 (3):321-7.
  83. Kim A, Jung B.H., Cadet P. (2014). A novel pathway by which the environmental toxin 4-nonylphenol may promote an inflammatory response in inflammatory bowel disease. Med Sci Monit Basic Res. Apr 10; 20: 47-54.