Robert M. Hoyte

   B.S. Long Island University
    M.S. Rutgers University
    Ph.D. Rutgers University
Distinguished Teaching Professor
MARC/MBRS Program Director

Dept: Chemistry and Physics

Building: Natural Sciences

Room: S257

Office Hours: 

Tue & Thur: 1:30 - 3:00 p.m.

Wed: 10:00 a.m.- 12:00 N

Phone: (516) 876 2754

E-mail: HoyteR@oldwestbury.edu

Organic Chemistry I, CP 3300
Organic Chemistry I Lab, CP 3302
Organic Chemistry II, CP 3310
Organic Chemistry II Lab, CP 3312
Advanced Organic Chemistry, CP 4320

Dr. Hoyte is Director of the following institutional programs in which several other faculty members and many students participate.

Minority Access to Research Careers (MARC) Program

Provides biomedical research training to underrepresented minority students.  Lower division students receive academic support and science enrichment experiences.  Upper division students participate in biomedical research and receive tuition assistance and stipends through the Undergraduate Student Academic Research (U*STAR) component. 

For information call (516) 876 3041.
Funded by the National Institute of General Medical Sciences.

Minority Biomedical Research Support (MBRS) Program

This program supports faculty research through a competitive award mechanism.  Some research projects provide salary funds that can support students doing summer and academic year research in biomedical fields. 

For information call (516) 876 3041.
Funded by the National Institute of General Medical Sciences.

 
Synthesis of Androgen and Glucocorticoid Receptor Ligands

Research in Dr. Hoyte’s laboratory has contributed to progress toward the development of compounds useful in cancer diagnosis and valuable in studies aimed at understanding psychiatric disorders such as depression.  The work centers on the design and synthesis of halogenated derivatives and analogs of steroid hormones that retain affinity for their cellular receptors and that can be prepared by procedures that permit the incorporation of radioactive iodine (¹²³I) and fluorine (¹⁸F).  Over 20 publications and one patent have resulted from Dr. Hoyte’s work in this and related areas of steroid chemistry. Current target compounds are androgens and glucocorticoids. The radiohalogenated androgens have great utility for In-vivo imaging of androgen receptor (AR) containing tissues where ¹²³I-labeled compounds can be used in single photon emission computed tomography (SPECT) and ¹⁸F-labeled androgens are important because of their applications in positron emission tomography (PET).  These sensitive methods are important for the detection of androgen responsive tumors such as prostate cancer as well as the metastases that may follow. Thus the labeled compounds are expected to be useful in monitoring the progress of cancer patients in therapy.  Labeled compounds with glucocorticoid activity will be valuable in mapping and imaging of glucocorticoid receptor (GR) rich regions of the brain using SPECT (¹²³I-labeled compounds) and PET (¹⁸F-labeled compounds). Such studies are of increasing importance in defining and understanding the role and function of corticosteroids in the brain where they are reputed to be involved in psychiatric disorders such as depression and in the management of stress.

 The involvement of undergraduate students in research has been a significant feature of Dr. Hoyte’s projects and seven students trained in his laboratory now hold doctoral degrees.  Three others are currently pursuing doctoral studies.  More than half of these students have earned co-authorship of publications with Dr. Hoyte.

“The Synthesis and Testing of E-17a-(2-iodovinyl)-5a-Dihydro- testosterone and Z-17a-(2-iodovinyl)-5a-Dihydrotestosterone as Gamma Emitting Ligands for the Androgen Receptor”, R.M. Hoyte, N.J. MacLusky and R.B. Hochberg, J. Steroid Biochemistry, 36, 125-132 (1990).

“7a-Methyl-17a-(E-2’-[¹²⁵I]iodovinyl)-19-nortestosterone: A New Radio-ligand for the Detection of Androgen Receptor”,  R.M. Hoyte, T.J. Brown, N.J. MacLusky and R.B. Hochberg, Steroids, 58, 13-23 (1993).

“Synthesis and Evaluation of 7a-iodo-5a-Dihydrotestosterone as a Potential Radioligand for Androgen Receptor”.   R.M. Hoyte, K. Borderon, K. Bryson, R. Allen , R.B. Hochberg  and T.J. Brown, J. Medicinal. Chem., 37, 1224-1230 (1994).

“Radiolabeled 7a-iodo-5a-dihydrotestosterone:  A new radioligand for androgen receptor”.  R.M. Hoyte, D. Labaree, T.J. Brown, and R.B. Hochberg.  Quarterly J. Nuclear Med.,  39, 62-63 (1995)

7a-[¹²⁵I]iodo-5a-dihydrotestosterone:  A Radiolabeled Ligand  for the Androgen Receptor".  D. C. Labaree, T.J. Brown, R.M. Hoyte, and R.B. Hochberg.  J. Nuclear Medicine,  38, 402-409 (1997).

“A Direct Stereoselective Synthesis of 7a-Hydroxytestosterone” . D. Labaree, R.M. Hoyte,  and R.B. Hochberg.  Steroids,  62, 482-486 (1997).

“Iodinated and Fluorinated Steroid 2’-Aryl-[3,2-c]pyrazoles as Potential Glucocorticoid Receptor Imaging Agents.” R.M. Hoyte, D.C. Labaree, J.M. Fede, C. Harris and R.B. Hochberg. Steroids, 63, 595-602 (1998).

“7a-Iodo- and Fluoro- Steroids as Androgen Receptor Mediated Imaging Agents”, D.C. Labaree, R.M. Hoyte, L.V. Nazareth, N. Weigel and R.B. Hochberg, J. Medicinal Chemistry, 42, 2021-2034 (1999).

“[7a-¹⁸F]Fluoro-17 a-methyl-5a-dihydrotestosterone: A Ligand for Androgen Receptor-Mediated Imaging of Prostate Cancer. P. Garg, D.C. Labaree, R.M. Hoyte, and R.B. Hochberg, Nuclear Medicine and Biology, 28, 85-90 (2001).

“Synthesis of Halogen-Substituted Pyridyl and Pyrimidyl Derivatives of [3,2-c]Pyrazolo Corticosteroids:  Strategies for the Development of Glucocorticoid Receptor Mediated Imaging Agents.”  R. M. Hoyte, J. Zhang, R. Lerum, A. Oluyemi, P. Persaud,  C. O’Connor, D. C. Labaree and R. B. Hochberg, Journal of Medicinal Chemistry, 45, 5397-5405 (2002).

“Microwave-enhanced nucleophilic fluorination in the synthesis of fluoropyridyl derivatives of [3,2-c]pyrazolo-corticosteroids, potential glucocorticoid receptor-mediated imaging agents.” M.G.C. Kahn, E. Konde; F.Dossou, D.C. Labaree, R. B. Hochberg and R. M. Hoyte, Bioorganic and Medicinal Chemistry Letters , 16 , 3454-3458 (2006).